Cantargia: första patienten behandlad med antikroppen

Analysguiden: Andra halvlek i CANFOUR - IPO.se

I enlighet med protokollet behandlas patienterna i grupper om tre. Cantargia AB today announced that the first patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, in Cantargia AB today announced that the first patient with pancreatic cancer has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and | April 6, 2021 Cantargia’s Phase IIa CANFOUR trial investigates CAN04 in a combination with a different chemotherapy (platinum-based as opposed to docetaxel in the Novartis trial) and CAN04 blocks the signalling from both IL-1alpha and IL-1beta (recent interim data from the CANFOUR trial was positive). Cantargia AB meddelade idag uppdaterade interimsresultat från den pågående kliniska studien med antikroppen CAN04, som blockerar interleukin-1 receptor accessory protein (IL1RAP), i kombination Cantargia AB meddelade idag att alla 31 planerade patienter med bukspottkörtelcancer (PDAC) har påbörjat behandling i CANFOUR-studien som undersöker kombination av CAN04 med cellgifter. I den del av CANFOUR som innefattar PDAC behandlas fortfarande 9 av 31 patienter i den primära kohorten med CAN04 i kombination med gemcitabin och nab-paclitaxel.

9 Mar 2021 Can04 (nidanilimab), Cantargia, Anti-IL1RAP MAb, Solid tumours incl pancreatic cancer & NSCLC, Ph2 Canfour (NCT03267316), completed CANFOUR. 37 KB. Open-Label-Studie, Dosiseskalation gefolgt von Dosisexpansion, Sicherheits- und Tolerierbarkeitsstudie von CAN04, einem vollständig The main project, the antibody CAN04 (nidanilimab) is being studied in the clinical phase I/IIa CANFOUR with a primary focus on non-small cell lung cancer and 8 Apr 2020 CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining first line chemotherapy combination with two different First part of CANFOUR is nearing completion – Updated 16 May 2018 Cantargia's lead candidate is the antibody CAN04, which has a dual mechanism of 30 Aug 2017 A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors ( CANFOUR) Brief Summary: This study will evaluate the safety, 15 Dec 2020 The main project, the antibody CAN04, is being studied clinically as In the first phase I/IIa-study, CANFOUR, first line combination therapy is At bestemme den maksimalt tolererede dosis (MTD) af CAN04 og fastlægge anbefalet fase 2 dosis (RP2D) af CAN04 givet 1 gang ugentligt hos patienter med Cantargia ansöker om start av ny klinisk studie kring antikroppen CAN04 och första patienten med behandlats i fas IIa extensionsdel av CANFOUR-studien i 10 Mar 2021 CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used Cantargia's Phase IIa CANFOUR trial investigates CAN04 in a combination with a different chemotherapy (platinum-based as opposed to docetaxel in the 23 Aug 2019 The investigational antibody CAN04 binds IL1RAP with high affinity and clinical phase I/IIa CANFOUR with a primary focus on non-small cell CAN04 er utviklet som et nytt medikament og er et monoklonalt antistoff som eller bukspyttkjertelkreft - Utprøving av studielegemidlet CAN04 (CANFOUR). 1 jun 2019 tolerability trial of CAN04 (nidanilimab), a fully humanized monoclonal antibody CANFOUR – Phase I study design. 5.

Commissioned Research: Cantargia Nordea Markets

Sedan början av 2019 driver Cantargia en fas 2a-studie, (CANFOUR) på patienter med metastaserad lung- och bukspottkörtelcancer utan tidigare behandling med cellgifter. Preliminära interimsdata som bolaget presenterade i december i Cantargia reports first patient treated in CANFOUR pancreatic cancer phase IIa extension cohort Wed, Feb 10, 2021 13:30 CET. Cantargia AB today announced that the first patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and chemotherapy. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighet med det kliniska protokollet. I CANFOUR undersöks behandling med antikroppen CAN04 v Cantargia AB today announced that all 31 pancreatic cancer (PDAC) patients planned in the CANFOUR trial investigating combination of CAN04 and chemotherapy have started treatment.

Cantargia genomför riktad nyemission om cirka 106 miljoner

Studie population är Bukspottskörtelcancer och Icke småcellig lungcancer.

An interim analysis of 20 patients in October 2020 showed a 40% response rate (including 2 patients that had not been treated long enough for a second confirmatory CT-scan), which is higher than 23% reported as historical control 1 . Cantargia´s antibody CAN04 (nidanilimab) is investigated in an open label three-armed phase IIa clinical trial, CANFOUR. Here, CAN04 is examined as monotherapy or in chemotherapy combinations in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC). All 20 patients planned for one of these arms, monotherapy, CanFour är en Fas-1 studie med en ny läkemedel Can04. Can04 är en antikropp som har IL-1RAP som mål. Verkningsmekanism tros vara en minskning av inflammation i tumörens´mikromiljön + ADCC + stimulering av NK celler. Studie population är Bukspottskörtelcancer och Icke småcellig lungcancer.
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I den del av CANFOUR som innefattar PDAC behandlas fortfarande 9 av 31 patienter i den primära kohorten med CAN04 i kombination med gemcitabin och nab-paclitaxel.

Upplägget skiljer sig från CANFOUR-programmet, som befinner sig i slutet av fas 2a.
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CANFOUR - RCC - Regionala cancercentrum

An interim analysis of 20 patients in October 2020 showed a 40% response rate (including 2 patients that had not been treated long enough for a second confirmatory CT-scan), which is higher than 23% reported as historical control[1]. Cantargia: första patienten behandlad med antikroppen CAN04 i fas IIa-delen av CANFOUR-studien fre, jan 25, 2019 08:30 CET. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighet med det kliniska protokollet.

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CAN04 is presently investigated in combination with pembrolizumab (a common immunotherapy) to study the combination of these two immunotherapies.